Association between Helicobacter pylori infection, eradication and diabetes mellitus

Abstract Aims/Introduction It is suspected that Helicobacter pylori is associated with extradigestive diseases including diabetes. So far, a number of studies have examined the association between H. pylori and diabetes, and the results were conflicting. The aim of the present study was to examine t...

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Main Authors: Masayuki Kato, Akiko Toda, Ritsuko Yamamoto‐Honda, Yasuji Arase, Hirohito Sone
Format: Article
Language:English
Published: Wiley 2019-09-01
Series:Journal of Diabetes Investigation
Subjects:
Online Access:https://doi.org/10.1111/jdi.13011
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spelling doaj-2f5043bdf26c475499fe2647fe6f65d42021-05-02T13:55:58ZengWileyJournal of Diabetes Investigation2040-11162040-11242019-09-011051341134610.1111/jdi.13011Association between Helicobacter pylori infection, eradication and diabetes mellitusMasayuki Kato0Akiko Toda1Ritsuko Yamamoto‐Honda2Yasuji Arase3Hirohito Sone4Health Management Center Toranomon Hospital Tokyo JapanHealth Management Center Toranomon Hospital Tokyo JapanHealth Management Center Toranomon Hospital Tokyo JapanHealth Management Center Toranomon Hospital Tokyo JapanDepartment of Internal Medicine (Metabolism) Faculty of Medicine Niigata University Niigata JapanAbstract Aims/Introduction It is suspected that Helicobacter pylori is associated with extradigestive diseases including diabetes. So far, a number of studies have examined the association between H. pylori and diabetes, and the results were conflicting. The aim of the present study was to examine the association between H. pylori infection, eradication and diabetes. Materials and Methods The present cross‐sectional study was carried out using data from annual health checkups carried out at the Toranomon Hospital Health Management Center. The status of H. pylori infection, determined by serum antibodies and history of eradication, was categorized into three groups as “never,” “current” and “past.” The association between H. pylori infection and diabetes was examined using logistic regression. Results Of 21,634 participants, 6,530 (30.2%) had a current or past history of H. pylori infection, and 1,184 (5.5%) were identified as having diabetes. Multivariate adjusted odds ratios for diabetes compared with the “never” group were 1.36 (95% confidence interval 1.10–1.67) for the “current” group and 0.92 (95% confidence interval 0.79–1.07) for the “past” group. The association between H. pylori infection and diabetes was also observed among participants without a history of eradication. Conclusions We found that current H. pylori infection was associated with an increased risk of diabetes, and the increased risk was not observed among participants after eradication. The results were concordant with the hypothesis that H. pylori infection increases the risk of diabetes. Further studies are necessary to validate the present results.https://doi.org/10.1111/jdi.13011EradicationHelicobacter pyloriInflammation
collection DOAJ
language English
format Article
sources DOAJ
author Masayuki Kato
Akiko Toda
Ritsuko Yamamoto‐Honda
Yasuji Arase
Hirohito Sone
spellingShingle Masayuki Kato
Akiko Toda
Ritsuko Yamamoto‐Honda
Yasuji Arase
Hirohito Sone
Association between Helicobacter pylori infection, eradication and diabetes mellitus
Journal of Diabetes Investigation
Eradication
Helicobacter pylori
Inflammation
author_facet Masayuki Kato
Akiko Toda
Ritsuko Yamamoto‐Honda
Yasuji Arase
Hirohito Sone
author_sort Masayuki Kato
title Association between Helicobacter pylori infection, eradication and diabetes mellitus
title_short Association between Helicobacter pylori infection, eradication and diabetes mellitus
title_full Association between Helicobacter pylori infection, eradication and diabetes mellitus
title_fullStr Association between Helicobacter pylori infection, eradication and diabetes mellitus
title_full_unstemmed Association between Helicobacter pylori infection, eradication and diabetes mellitus
title_sort association between helicobacter pylori infection, eradication and diabetes mellitus
publisher Wiley
series Journal of Diabetes Investigation
issn 2040-1116
2040-1124
publishDate 2019-09-01
description Abstract Aims/Introduction It is suspected that Helicobacter pylori is associated with extradigestive diseases including diabetes. So far, a number of studies have examined the association between H. pylori and diabetes, and the results were conflicting. The aim of the present study was to examine the association between H. pylori infection, eradication and diabetes. Materials and Methods The present cross‐sectional study was carried out using data from annual health checkups carried out at the Toranomon Hospital Health Management Center. The status of H. pylori infection, determined by serum antibodies and history of eradication, was categorized into three groups as “never,” “current” and “past.” The association between H. pylori infection and diabetes was examined using logistic regression. Results Of 21,634 participants, 6,530 (30.2%) had a current or past history of H. pylori infection, and 1,184 (5.5%) were identified as having diabetes. Multivariate adjusted odds ratios for diabetes compared with the “never” group were 1.36 (95% confidence interval 1.10–1.67) for the “current” group and 0.92 (95% confidence interval 0.79–1.07) for the “past” group. The association between H. pylori infection and diabetes was also observed among participants without a history of eradication. Conclusions We found that current H. pylori infection was associated with an increased risk of diabetes, and the increased risk was not observed among participants after eradication. The results were concordant with the hypothesis that H. pylori infection increases the risk of diabetes. Further studies are necessary to validate the present results.
topic Eradication
Helicobacter pylori
Inflammation
url https://doi.org/10.1111/jdi.13011
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