Association between Helicobacter pylori infection, eradication and diabetes mellitus
Abstract Aims/Introduction It is suspected that Helicobacter pylori is associated with extradigestive diseases including diabetes. So far, a number of studies have examined the association between H. pylori and diabetes, and the results were conflicting. The aim of the present study was to examine t...
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doaj-2f5043bdf26c475499fe2647fe6f65d42021-05-02T13:55:58ZengWileyJournal of Diabetes Investigation2040-11162040-11242019-09-011051341134610.1111/jdi.13011Association between Helicobacter pylori infection, eradication and diabetes mellitusMasayuki Kato0Akiko Toda1Ritsuko Yamamoto‐Honda2Yasuji Arase3Hirohito Sone4Health Management Center Toranomon Hospital Tokyo JapanHealth Management Center Toranomon Hospital Tokyo JapanHealth Management Center Toranomon Hospital Tokyo JapanHealth Management Center Toranomon Hospital Tokyo JapanDepartment of Internal Medicine (Metabolism) Faculty of Medicine Niigata University Niigata JapanAbstract Aims/Introduction It is suspected that Helicobacter pylori is associated with extradigestive diseases including diabetes. So far, a number of studies have examined the association between H. pylori and diabetes, and the results were conflicting. The aim of the present study was to examine the association between H. pylori infection, eradication and diabetes. Materials and Methods The present cross‐sectional study was carried out using data from annual health checkups carried out at the Toranomon Hospital Health Management Center. The status of H. pylori infection, determined by serum antibodies and history of eradication, was categorized into three groups as “never,” “current” and “past.” The association between H. pylori infection and diabetes was examined using logistic regression. Results Of 21,634 participants, 6,530 (30.2%) had a current or past history of H. pylori infection, and 1,184 (5.5%) were identified as having diabetes. Multivariate adjusted odds ratios for diabetes compared with the “never” group were 1.36 (95% confidence interval 1.10–1.67) for the “current” group and 0.92 (95% confidence interval 0.79–1.07) for the “past” group. The association between H. pylori infection and diabetes was also observed among participants without a history of eradication. Conclusions We found that current H. pylori infection was associated with an increased risk of diabetes, and the increased risk was not observed among participants after eradication. The results were concordant with the hypothesis that H. pylori infection increases the risk of diabetes. Further studies are necessary to validate the present results.https://doi.org/10.1111/jdi.13011EradicationHelicobacter pyloriInflammation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Masayuki Kato Akiko Toda Ritsuko Yamamoto‐Honda Yasuji Arase Hirohito Sone |
spellingShingle |
Masayuki Kato Akiko Toda Ritsuko Yamamoto‐Honda Yasuji Arase Hirohito Sone Association between Helicobacter pylori infection, eradication and diabetes mellitus Journal of Diabetes Investigation Eradication Helicobacter pylori Inflammation |
author_facet |
Masayuki Kato Akiko Toda Ritsuko Yamamoto‐Honda Yasuji Arase Hirohito Sone |
author_sort |
Masayuki Kato |
title |
Association between Helicobacter pylori infection, eradication and diabetes mellitus |
title_short |
Association between Helicobacter pylori infection, eradication and diabetes mellitus |
title_full |
Association between Helicobacter pylori infection, eradication and diabetes mellitus |
title_fullStr |
Association between Helicobacter pylori infection, eradication and diabetes mellitus |
title_full_unstemmed |
Association between Helicobacter pylori infection, eradication and diabetes mellitus |
title_sort |
association between helicobacter pylori infection, eradication and diabetes mellitus |
publisher |
Wiley |
series |
Journal of Diabetes Investigation |
issn |
2040-1116 2040-1124 |
publishDate |
2019-09-01 |
description |
Abstract Aims/Introduction It is suspected that Helicobacter pylori is associated with extradigestive diseases including diabetes. So far, a number of studies have examined the association between H. pylori and diabetes, and the results were conflicting. The aim of the present study was to examine the association between H. pylori infection, eradication and diabetes. Materials and Methods The present cross‐sectional study was carried out using data from annual health checkups carried out at the Toranomon Hospital Health Management Center. The status of H. pylori infection, determined by serum antibodies and history of eradication, was categorized into three groups as “never,” “current” and “past.” The association between H. pylori infection and diabetes was examined using logistic regression. Results Of 21,634 participants, 6,530 (30.2%) had a current or past history of H. pylori infection, and 1,184 (5.5%) were identified as having diabetes. Multivariate adjusted odds ratios for diabetes compared with the “never” group were 1.36 (95% confidence interval 1.10–1.67) for the “current” group and 0.92 (95% confidence interval 0.79–1.07) for the “past” group. The association between H. pylori infection and diabetes was also observed among participants without a history of eradication. Conclusions We found that current H. pylori infection was associated with an increased risk of diabetes, and the increased risk was not observed among participants after eradication. The results were concordant with the hypothesis that H. pylori infection increases the risk of diabetes. Further studies are necessary to validate the present results. |
topic |
Eradication Helicobacter pylori Inflammation |
url |
https://doi.org/10.1111/jdi.13011 |
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