S-Adenosyl-L-Homocysteine Hydrolase Inhibition by a Synthetic Nicotinamide Cofactor Biomimetic

S-Adenosyl-L-Homocysteine Hydrolase Inhibition by a Synthetic Nicotinamide Cofactor Biomimetic

S-adenosyl-L-homocysteine (SAH) hydrolases (SAHases) are involved in the regulation of methylation reactions in many organisms and are thus crucial for numerous cellular functions. Consequently, their dysregulation is associated with severe health problems. The SAHase-catalyzed reaction is reversibl...

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Bibliographic Details
Main Authors: Lyn L. Kailing, Daniela Bertinetti, Caroline E. Paul, Tomasz Manszewski, Mariusz Jaskolski, Friedrich W. Herberg, Ioannis V. Pavlidis
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Microbiology
Subjects:
S-adenosyl-L-homocysteine hydrolase
inhibition
nicotinamide cofactor
biomimetic
crystallography
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00505/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2018.00505/full

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