Blastic plasmacytoid dendritic cell neoplasm: Case report and literature overview
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a malignancy with high frequency of skin involvement. A 39-year-old Caucasian female was suffering from weakness, myalgia, and skin eruption, which appeared during treatment of chlamydiosis with antibiotics in July 2016. Based on clinical prese...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2020-01-01
|
Series: | Indian Journal of Dermatology |
Subjects: | |
Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2020;volume=65;issue=3;spage=217;epage=221;aulast=Kolerova |
id |
doaj-2fd28b86e7774d859937047d63e1f43a |
---|---|
record_format |
Article |
spelling |
doaj-2fd28b86e7774d859937047d63e1f43a2020-11-25T02:25:37ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112020-01-0165321722110.4103/ijd.IJD_235_18Blastic plasmacytoid dendritic cell neoplasm: Case report and literature overviewAnastasiia KolerovaIrina SergeevaJulia KrinitsynaNatalia PronkinaSvetlana SizikovaPavel FilimonovIrina KryuchkovaBlastic plasmacytoid dendritic cell neoplasm (BPDCN) is a malignancy with high frequency of skin involvement. A 39-year-old Caucasian female was suffering from weakness, myalgia, and skin eruption, which appeared during treatment of chlamydiosis with antibiotics in July 2016. Based on clinical presentation, laboratory investigations, and histological examination of skin and bone marrow biopsy, a diagnosis of BPDCN with the involvement of skin, bone marrow, and central nervous system was made. The patient was put on acute lymphoblastic leukemia-like chemotherapy and achieved complete remission in November 2016, the eruption regressed. In January 2017, allogeneic bone marrow transplantation from matched sibling was performed. Since May 2017, the cutaneous relapse with loss of CD56 expression has developed. This clinical case demonstrates the importance of laboratory tests. Histological examination helps to clarify a diagnosis of cutaneous lymphoma; however, a specific type of lymphoma needs immunohistochemical analysis. In our case, BPDCN at the initial stage presented like a systemic vasculitis.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2020;volume=65;issue=3;spage=217;epage=221;aulast=Kolerovablastic plasmacytoid dendritic cell neoplasmcutaneous lymphomacutaneous oncology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anastasiia Kolerova Irina Sergeeva Julia Krinitsyna Natalia Pronkina Svetlana Sizikova Pavel Filimonov Irina Kryuchkova |
spellingShingle |
Anastasiia Kolerova Irina Sergeeva Julia Krinitsyna Natalia Pronkina Svetlana Sizikova Pavel Filimonov Irina Kryuchkova Blastic plasmacytoid dendritic cell neoplasm: Case report and literature overview Indian Journal of Dermatology blastic plasmacytoid dendritic cell neoplasm cutaneous lymphoma cutaneous oncology |
author_facet |
Anastasiia Kolerova Irina Sergeeva Julia Krinitsyna Natalia Pronkina Svetlana Sizikova Pavel Filimonov Irina Kryuchkova |
author_sort |
Anastasiia Kolerova |
title |
Blastic plasmacytoid dendritic cell neoplasm: Case report and literature overview |
title_short |
Blastic plasmacytoid dendritic cell neoplasm: Case report and literature overview |
title_full |
Blastic plasmacytoid dendritic cell neoplasm: Case report and literature overview |
title_fullStr |
Blastic plasmacytoid dendritic cell neoplasm: Case report and literature overview |
title_full_unstemmed |
Blastic plasmacytoid dendritic cell neoplasm: Case report and literature overview |
title_sort |
blastic plasmacytoid dendritic cell neoplasm: case report and literature overview |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Dermatology |
issn |
0019-5154 1998-3611 |
publishDate |
2020-01-01 |
description |
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a malignancy with high frequency of skin involvement. A 39-year-old Caucasian female was suffering from weakness, myalgia, and skin eruption, which appeared during treatment of chlamydiosis with antibiotics in July 2016. Based on clinical presentation, laboratory investigations, and histological examination of skin and bone marrow biopsy, a diagnosis of BPDCN with the involvement of skin, bone marrow, and central nervous system was made. The patient was put on acute lymphoblastic leukemia-like chemotherapy and achieved complete remission in November 2016, the eruption regressed. In January 2017, allogeneic bone marrow transplantation from matched sibling was performed. Since May 2017, the cutaneous relapse with loss of CD56 expression has developed. This clinical case demonstrates the importance of laboratory tests. Histological examination helps to clarify a diagnosis of cutaneous lymphoma; however, a specific type of lymphoma needs immunohistochemical analysis. In our case, BPDCN at the initial stage presented like a systemic vasculitis. |
topic |
blastic plasmacytoid dendritic cell neoplasm cutaneous lymphoma cutaneous oncology |
url |
http://www.e-ijd.org/article.asp?issn=0019-5154;year=2020;volume=65;issue=3;spage=217;epage=221;aulast=Kolerova |
work_keys_str_mv |
AT anastasiiakolerova blasticplasmacytoiddendriticcellneoplasmcasereportandliteratureoverview AT irinasergeeva blasticplasmacytoiddendriticcellneoplasmcasereportandliteratureoverview AT juliakrinitsyna blasticplasmacytoiddendriticcellneoplasmcasereportandliteratureoverview AT nataliapronkina blasticplasmacytoiddendriticcellneoplasmcasereportandliteratureoverview AT svetlanasizikova blasticplasmacytoiddendriticcellneoplasmcasereportandliteratureoverview AT pavelfilimonov blasticplasmacytoiddendriticcellneoplasmcasereportandliteratureoverview AT irinakryuchkova blasticplasmacytoiddendriticcellneoplasmcasereportandliteratureoverview |
_version_ |
1724850951462846464 |