How does the NPM1 mutant induce leukemia?
NPM1 is the most frequently mutated gene in AML and the role of the NPM1 mutant in acute myeloid leukemia along with its leukemogenic potential are still under investigation. NPM1 genetic alterations can contribute to leukemogenesis through the direct oncogenic effect of the mutant protein and the c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-06-01
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| Series: | Pediatric Reports |
| Online Access: | https://www.pagepress.org/journals/index.php/pr/article/view/2823 |