The Wilms tumor gene, Wt1, is critical for mouse spermatogenesis via regulation of sertoli cell polarity and is associated with non-obstructive azoospermia in humans.

The Wilms tumor gene, Wt1, is critical for mouse spermatogenesis via regulation of sertoli cell polarity and is associated with non-obstructive azoospermia in humans.

Azoospermia is one of the major reproductive disorders which cause male infertility in humans; however, the etiology of this disease is largely unknown. In the present study, six missense mutations of WT1 gene were detected in 529 human patients with non-obstructive azoospermia (NOA), indicating a s...

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Bibliographic Details
Main Authors: Xiao Na Wang, Ze Song Li, Yu Ren, Tao Jiang, Ya Qing Wang, Min Chen, Jun Zhang, Jian Xiu Hao, Yan Bo Wang, Ri Na Sha, Yi Huang, Xiao Liu, Jing Chu Hu, Guang Qing Sun, Hong Gang Li, Cheng Liang Xiong, Jun Xie, Zhi Mao Jiang, Zhi Ming Cai, Jun Wang, Jian Wang, Vicki Huff, Yao Ting Gui, Fei Gao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3731222?pdf=render

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http://europepmc.org/articles/PMC3731222?pdf=render

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