MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6

MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6

Abstract Background The human myxovirus resistance 2 (Mx2/MxB) protein was originally found to regulate cytoplasmic-nuclear transport but was recently reported to restrict HIV-1 replication by binding to HIV-1 capsid (CA), preventing uncoating, the nuclear import of pre-integration complex (PIC) and...

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Bibliographic Details
Main Authors: Linlin Xie, Lang Chen, Chaojie Zhong, Ting Yu, Zhao Ju, Meirong Wang, Hairong Xiong, Yan Zeng, Jianhua Wang, Haitao Hu, Wei Hou, Yong Feng
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Retrovirology
Subjects:
HIV-1
Nuclear import
Nucleoporin
MxB
CPSF6
Online Access:http://link.springer.com/article/10.1186/s12977-020-00524-2

Internet

http://link.springer.com/article/10.1186/s12977-020-00524-2

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