SARS-CoV-2 Switches ‘on’ MAPK and NFκB Signaling via the Reduction of Nuclear DUSP1 and DUSP5 Expression

SARS-CoV-2 Switches ‘on’ MAPK and NFκB Signaling via the Reduction of Nuclear DUSP1 and DUSP5 Expression

Mitogen-activated protein kinases (MAPK) and NF-kappaB (NF-κB) pathway regulate many cellular processes and are essential for immune cells function. Their activity is controlled by dual-specificity phosphatases (DUSPs). A comprehensive analysis of publicly available gene expression data sets of huma...

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Bibliographic Details
Main Authors: Swati Goel, Fatemeh Saheb Sharif-Askari, Narjes Saheb Sharif Askari, Bushra Madkhana, Ahmad Munzer Alwaa, Bassam Mahboub, Adel M Zakeri, Elaref Ratemi, Rifat Hamoudi, Qutayba Hamid, Rabih Halwani
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
SARS-CoV-2
COVID-19
MAPK
NFkB
DUSP1
DUSP5
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.631879/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.631879/full

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