Evaluation of a Novel Plasmid for Simultaneous Gene Electrotransfer-Mediated Silencing of CD105 and CD146 in Combination with Irradiation

Evaluation of a Novel Plasmid for Simultaneous Gene Electrotransfer-Mediated Silencing of CD105 and CD146 in Combination with Irradiation

Targeting tumor vasculature through specific endothelial cell markers represents a promising approach for cancer treatment. Here our aim was to construct an antibiotic resistance gene-free plasmid encoding shRNAs to simultaneously target two endothelial cell markers, CD105 and CD146, and to test its...

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Bibliographic Details
Main Authors: Monika Savarin, Urska Kamensek, Katarina Znidar, Vesna Todorovic, Gregor Sersa, Maja Cemazar
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
CD105
CD146
plasmid
gene electrotransfer
antibiotic-free
irradiation
Online Access:https://www.mdpi.com/1422-0067/22/6/3069

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https://www.mdpi.com/1422-0067/22/6/3069

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