GSK3α and GSK3β Phosphorylate Arc and Regulate its Degradation

GSK3α and GSK3β Phosphorylate Arc and Regulate its Degradation

The selective and neuronal activity-dependent degradation of synaptic proteins appears to be crucial for long-term synaptic plasticity. One such protein is activity-regulated cytoskeleton-associated protein (Arc), which regulates the synaptic content of α-amino-3-hydroxy-5-methyl-4-isoxazolepropioni...

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Bibliographic Details
Main Authors: Agata Gozdz, Oleksii Nikolaienko, Malgorzata Urbanska, Iwona A. Cymerman, Ewa Sitkiewicz, Magdalena Blazejczyk, Michal Dadlez, Clive R. Bramham, Jacek Jaworski
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Arc/Arg3.1
GSK3
proteasomal degradation
phosphorylation
dendritic spines
neuronal activity
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00192/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00192/full

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