High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity

High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity

Abstract Therapeutic developments for neurodegenerative disorders are redirecting their focus to the mechanisms that contribute to neuronal connectivity and the loss thereof. Using a high-throughput microscopy pipeline that integrates morphological and functional measurements, we found that inhibiti...

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Bibliographic Details
Main Authors: Marlies Verschuuren, Peter Verstraelen, Gerardo García-Díaz Barriga, Ines Cilissen, Emma Coninx, Mieke Verslegers, Peter H. Larsen, Rony Nuydens, Winnok H. De Vos
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Acta Neuropathologica Communications
Subjects:
Neuronal connectivity
Neuronal network
Synapse
Calcium imaging
High-content screening
Neurodegeneration
Online Access:http://link.springer.com/article/10.1186/s40478-019-0741-3

Internet

http://link.springer.com/article/10.1186/s40478-019-0741-3

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