EGFR/FOXO3a/BIM signaling pathway determines chemosensitivity of BMP4-differentiated glioma stem cells to temozolomide

Brain cancer: Stem cell properties may determine chemotherapy success The properties of individual glioma stem cells (GSCs) may influence the success of chemotherapy in tackling aggressive brain cancer. GSCs promote tumor growth and chemotherapy resistance in glioblastoma tumors. One potential treat...

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Bibliographic Details
Main Authors: Iwona Anna Ciechomska, Bartlomiej Gielniewski, Bartosz Wojtas, Bozena Kaminska, Jakub Mieczkowski
Format: Article
Language:English
Published: Nature Publishing Group 2020-08-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-020-0479-9