Grafting Neural Stem and Progenitor Cells Into the Hippocampus of Juvenile, Irradiated Mice Normalizes Behavior Deficits

Grafting Neural Stem and Progenitor Cells Into the Hippocampus of Juvenile, Irradiated Mice Normalizes Behavior Deficits

The pool of neural stem and progenitor cells (NSPCs) in the dentate gyrus of the hippocampus is reduced by ionizing radiation. This explains, at least partly, the learning deficits observed in patients after radiotherapy, particularly in pediatric cases. An 8 Gy single irradiation dose was delivered...

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Bibliographic Details
Main Authors: Yoshiaki Sato, Noriko Shinjyo, Machiko Sato, Marie K. L. Nilsson, Kazuhiro Osato, Changlian Zhu, Marcela Pekna, Hans G. Kuhn, Klas Blomgren
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Neurology
Subjects:
neural stem progenitor cells
irradiation
transplantation
grafting
learning deficits
developing brain
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.00715/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2018.00715/full

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