Evolutionary Divergence of Enzymatic Mechanisms for Tubulin Detyrosination

Evolutionary Divergence of Enzymatic Mechanisms for Tubulin Detyrosination

Summary: The two related members of the vasohibin family, VASH1 and VASH2, encode human tubulin detyrosinases. Here we demonstrate that, in contrast to VASH1, which requires binding of small vasohibin binding protein (SVBP), VASH2 has autonomous tubulin detyrosinating activity. Moreover, we demonstr...

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Bibliographic Details
Main Authors: Siem van der Laan, Maude F. Lévêque, Guillaume Marcellin, Lubomir Vezenkov, Yoann Lannay, Geronimo Dubra, Guillaume Bompard, Sara Ovejero, Serge Urbach, Andrew Burgess, Muriel Amblard, Yvon Sterkers, Patrick Bastien, Krzysztof Rogowski
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719315657

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http://www.sciencedirect.com/science/article/pii/S2211124719315657

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