High risk population isolate reveals low frequency variants predisposing to intracranial aneurysms.

High risk population isolate reveals low frequency variants predisposing to intracranial aneurysms.

3% of the population develops saccular intracranial aneurysms (sIAs), a complex trait, with a sporadic and a familial form. Subarachnoid hemorrhage from sIA (sIA-SAH) is a devastating form of stroke. Certain rare genetic variants are enriched in the Finns, a population isolate with a small founder p...

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Bibliographic Details
Main Authors: Mitja I Kurki, Emília Ilona Gaál, Johannes Kettunen, Tuuli Lappalainen, Androniki Menelaou, Verneri Anttila, Femke N G van 't Hof, Mikael von Und Zu Fraunberg, Seppo Helisalmi, Mikko Hiltunen, Hanna Lehto, Aki Laakso, Riku Kivisaari, Timo Koivisto, Antti Ronkainen, Jaakko Rinne, Lambertus A L Kiemeney, Sita H Vermeulen, Mari A Kaunisto, Johan G Eriksson, Arpo Aromaa, Markus Perola, Terho Lehtimäki, Olli T Raitakari, Veikko Salomaa, Murat Gunel, Emmanouil T Dermitzakis, Ynte M Ruigrok, Gabriel J E Rinkel, Mika Niemelä, Juha Hernesniemi, Samuli Ripatti, Paul I W de Bakker, Aarno Palotie, Juha E Jääskeläinen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3907358?pdf=render

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http://europepmc.org/articles/PMC3907358?pdf=render

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