Hypoxia Is a Critical Parameter for Chondrogenic Differentiation of Human Umbilical Cord Blood Mesenchymal Stem Cells in Type I/III Collagen Sponges

Hypoxia Is a Critical Parameter for Chondrogenic Differentiation of Human Umbilical Cord Blood Mesenchymal Stem Cells in Type I/III Collagen Sponges

Umbilical cord blood (UCB) is an attractive alternative to bone marrow for isolation of mesenchymal stem cells (MSCs) to treat articular cartilage defects. Here, we set out to determine the growth factors (bone morphogenetic protein 2 (BMP-2) and transforming growth factor-β (TGF-β1)) and oxygen ten...

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Bibliographic Details
Main Authors: Tangni Gómez-Leduc, Mélanie Desancé, Magalie Hervieu, Florence Legendre, David Ollitrault, Claire de Vienne, Michel Herlicoviez, Philippe Galéra, Magali Demoor
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:International Journal of Molecular Sciences
Subjects:
mesenchymal stem cells
umbilical cord blood
cartilage tissue engineering
hypoxia
chondrogenesis
Online Access:https://www.mdpi.com/1422-0067/18/9/1933

Internet

https://www.mdpi.com/1422-0067/18/9/1933

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