The Correlation Between Potential “Anti- Cancer” Trace Elements and the Risk of Breast Cancer: A Case-Control Study in a Chinese Population
BackgroundsBreast cancer is a heterogeneous disease without clear pathogenesis and effective primary prevention. The “anti-cancer” effects of several trace elements have received increasing attention in recent years. The main purpose of current study is to explore the differences of three potential...
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doaj-3333417c116b434eae7a62e8e3aa04212021-08-10T06:49:45ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-08-011110.3389/fonc.2021.646534646534The Correlation Between Potential “Anti- Cancer” Trace Elements and the Risk of Breast Cancer: A Case-Control Study in a Chinese PopulationHeng Xue0Rui Qiao1Lailai Yan2Lailai Yan3Siyu Yang4Yongming Liang5Yaqiong Liu6Yaqiong Liu7Qing Xie8Qing Xie9Ligang Cui10Bing Cao11Department of Ultrasound, Peking University Third Hospital, Beijing, ChinaBaotou Medical College, Inner Mongolia University of Science and Technology, Baotou, ChinaDepartment of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, ChinaVaccine Research Center, School of Public Health, Peking University, Beijing, ChinaTianjin Center for Disease Control and Prevention, Tianjin, ChinaDepartment of Laboratory Medicine, Peking University Third Hospital, Beijing, ChinaDepartment of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, ChinaVaccine Research Center, School of Public Health, Peking University, Beijing, ChinaDepartment of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, ChinaVaccine Research Center, School of Public Health, Peking University, Beijing, ChinaDepartment of Ultrasound, Peking University Third Hospital, Beijing, ChinaKey Laboratory of Cognition and Personality (SWU), Faculty of Psychology, Ministry of Education, Southwest University, Chongqing, ChinaBackgroundsBreast cancer is a heterogeneous disease without clear pathogenesis and effective primary prevention. The “anti-cancer” effects of several trace elements have received increasing attention in recent years. The main purpose of current study is to explore the differences of three potential “anti-cancer” trace elements selenium (Se), molybdenum (Mo), and strontium (Sr) between patients with malignant breast tumors and healthy controls.MethodsWe conducted a case–control study in 45 patients with malignant breast tumors as cases and 95 healthy volunteers as controls from Peking University Third Hospital, Beijing, China. The serum concentrations of trace elements were evaluated by using inductively coupled plasma mass spectrometry (ICP-MS).ResultsThe cases may have a lower Se levels when compared with controls (cases: 106.22 ng/ml, SD: 20.95 ng/ml; controls: 117.02 ng/ml, IQR: 22.79 ng/ml, p = 0.014). High levels of Se were a protective factor from breast cancer after adjusting the potential confounders of age, BMI, smoking, drinking, and menopause status (OR = 0.395, 95% CI, 0.178, 0.877, p = 0.023). The levels of Sr were lower in cases with high histologic grade when compared to low histologic grade (low histologic grade: 49.83 ng/ml, IQR: 41.35–62.60 ng/ml; high histologic grade: 40.19 ng/ml, IQR: 39.24–47.16 ng/ml, p < 0.05).ConclusionsOur findings herein supported that Se has protective effects to avoid malignant breast tumors and Sr has protective effects to avoid poorly differentiated malignant breast tumors. Exploring “anti-cancer” related trace elements and their associations with breast cancer will assist for the early prevention and intervention for the disease.https://www.frontiersin.org/articles/10.3389/fonc.2021.646534/fullseleniumstrontiumanti-cancermalignantICP-MS |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Heng Xue Rui Qiao Lailai Yan Lailai Yan Siyu Yang Yongming Liang Yaqiong Liu Yaqiong Liu Qing Xie Qing Xie Ligang Cui Bing Cao |
spellingShingle |
Heng Xue Rui Qiao Lailai Yan Lailai Yan Siyu Yang Yongming Liang Yaqiong Liu Yaqiong Liu Qing Xie Qing Xie Ligang Cui Bing Cao The Correlation Between Potential “Anti- Cancer” Trace Elements and the Risk of Breast Cancer: A Case-Control Study in a Chinese Population Frontiers in Oncology selenium strontium anti-cancer malignant ICP-MS |
author_facet |
Heng Xue Rui Qiao Lailai Yan Lailai Yan Siyu Yang Yongming Liang Yaqiong Liu Yaqiong Liu Qing Xie Qing Xie Ligang Cui Bing Cao |
author_sort |
Heng Xue |
title |
The Correlation Between Potential “Anti- Cancer” Trace Elements and the Risk of Breast Cancer: A Case-Control Study in a Chinese Population |
title_short |
The Correlation Between Potential “Anti- Cancer” Trace Elements and the Risk of Breast Cancer: A Case-Control Study in a Chinese Population |
title_full |
The Correlation Between Potential “Anti- Cancer” Trace Elements and the Risk of Breast Cancer: A Case-Control Study in a Chinese Population |
title_fullStr |
The Correlation Between Potential “Anti- Cancer” Trace Elements and the Risk of Breast Cancer: A Case-Control Study in a Chinese Population |
title_full_unstemmed |
The Correlation Between Potential “Anti- Cancer” Trace Elements and the Risk of Breast Cancer: A Case-Control Study in a Chinese Population |
title_sort |
correlation between potential “anti- cancer” trace elements and the risk of breast cancer: a case-control study in a chinese population |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2021-08-01 |
description |
BackgroundsBreast cancer is a heterogeneous disease without clear pathogenesis and effective primary prevention. The “anti-cancer” effects of several trace elements have received increasing attention in recent years. The main purpose of current study is to explore the differences of three potential “anti-cancer” trace elements selenium (Se), molybdenum (Mo), and strontium (Sr) between patients with malignant breast tumors and healthy controls.MethodsWe conducted a case–control study in 45 patients with malignant breast tumors as cases and 95 healthy volunteers as controls from Peking University Third Hospital, Beijing, China. The serum concentrations of trace elements were evaluated by using inductively coupled plasma mass spectrometry (ICP-MS).ResultsThe cases may have a lower Se levels when compared with controls (cases: 106.22 ng/ml, SD: 20.95 ng/ml; controls: 117.02 ng/ml, IQR: 22.79 ng/ml, p = 0.014). High levels of Se were a protective factor from breast cancer after adjusting the potential confounders of age, BMI, smoking, drinking, and menopause status (OR = 0.395, 95% CI, 0.178, 0.877, p = 0.023). The levels of Sr were lower in cases with high histologic grade when compared to low histologic grade (low histologic grade: 49.83 ng/ml, IQR: 41.35–62.60 ng/ml; high histologic grade: 40.19 ng/ml, IQR: 39.24–47.16 ng/ml, p < 0.05).ConclusionsOur findings herein supported that Se has protective effects to avoid malignant breast tumors and Sr has protective effects to avoid poorly differentiated malignant breast tumors. Exploring “anti-cancer” related trace elements and their associations with breast cancer will assist for the early prevention and intervention for the disease. |
topic |
selenium strontium anti-cancer malignant ICP-MS |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2021.646534/full |
work_keys_str_mv |
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