Post Zygotic, Somatic, Deletion in KERATIN 1 V1 Domain Generates Structural Alteration of the K1/K10 Dimer, Producing a Monolateral Palmar Epidermolytic Nevus

Post Zygotic, Somatic, Deletion in KERATIN 1 V1 Domain Generates Structural Alteration of the K1/K10 Dimer, Producing a Monolateral Palmar Epidermolytic Nevus

Palmoplantar keratodermas (PPKs) are characterized by thickness of stratum corneum and epidermal hyperkeratosis localized in palms and soles. PPKs can be epidermolytic (EPPK) or non epidermolytic (NEPPK). Specific mutations of keratin 16 (K16) and keratin 1 (K1) have been associated to EPPK, and NEP...

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Bibliographic Details
Main Authors: Sabrina Caporali, Biagio Didona, Mauro Paradisi, Alessandro Mauriello, Elena Campione, Mattia Falconi, Federico Iacovelli, Marilena Minieri, Massimo Pieri, Sergio Bernardini, Alessandro Terrinoni
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
EPPK
NEPPK
keratins
genodermatosis
mosaic
keratin structure
Online Access:https://www.mdpi.com/1422-0067/22/13/6901

Internet

https://www.mdpi.com/1422-0067/22/13/6901

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