Brain-Selective Estrogen Therapy Prevents Androgen Deprivation-Associated Hot Flushes in a Rat Model

Brain-Selective Estrogen Therapy Prevents Androgen Deprivation-Associated Hot Flushes in a Rat Model

Hot flushes are best-known for affecting menopausal women, but men who undergo life-saving castration due to androgen-sensitive prostate cancer also suffer from these vasomotor symptoms. Estrogen deficiency in these patients is a direct consequence of androgen deprivation, because estrogens (notably...

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Bibliographic Details
Main Authors: Istvan Merchenthaler, Malcolm Lane, Christina Stennett, Min Zhan, Vien Nguyen, Katalin Prokai-Tatrai, Laszlo Prokai
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Pharmaceuticals
Subjects:
prostate cancer
androgen deprivation
brain-selective estrogen prodrug
DHED
male hot flush
rat model
Online Access:https://www.mdpi.com/1424-8247/13/6/119

Internet

https://www.mdpi.com/1424-8247/13/6/119

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