Protective Effects of Cultivated Ginseng, Cultivated Wild Ginseng of Korean and Chinese Against CCl4 and t-BHP Induced Acute Hepatotoxicity in ICR Mice
Objectives : This study was aimed at investigating live protection mechanism of Cultivated Ginseng and Cultivated Wild Ginseng of Korean and Chinese by inducing liver toxicity through and t-BHP in mice and evaluated serological findings. Methods : Experiment groups was categorized into untreated...
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Korean Pharmacopuncture Institute
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doaj-33a11fdbaf124b6ca5bf32a53a095db52020-11-24T21:28:23ZengKorean Pharmacopuncture InstituteJournal of Pharmacopuncture2093-69662234-68562007-02-0110110110710.3831/KPI.2007.10.1.101Protective Effects of Cultivated Ginseng, Cultivated Wild Ginseng of Korean and Chinese Against CCl4 and t-BHP Induced Acute Hepatotoxicity in ICR MiceKim, Young-Jin0Park, Hee-Soo1Kwon, Ki-Rok2Kim, Ho-Hyun3Dept. of Acup & Moxibustion, College of Oriental Medicine, Sangji UniversityDept. of Acup & Moxibustion, College of Oriental Medicine, Sangji UniversityDept. of Acup & Moxibustion, College of Oriental Medicine, Sangji UniversityDept. of Physiology, College of Oriental Medicine, Semyung UniversityObjectives : This study was aimed at investigating live protection mechanism of Cultivated Ginseng and Cultivated Wild Ginseng of Korean and Chinese by inducing liver toxicity through and t-BHP in mice and evaluated serological findings. Methods : Experiment groups was categorized into untreated normal group, treated control group, and orally administered Cultivated Ginseng and Cultivated Wild Ginseng of Korean and Chinese experimental groups. At the termination of experiment, gross examination of the liver as well as Total bilirubin, AST, and ALT contents in the serum were evaluated. Results : 1. In the induced acute hepatotoxicity test, total bilirubin, AST and ALT didn't show significant differences between the control and experimental groups. 2. In the t-BHP induced acute hepatotoxicity test, total bilirubin, AST and ALT didn't show significant differences between the control and experimental groups. Conclusion : Taken together, Cultivated Ginseng and Cultivated Wild Ginseng of Korean and Chinese cannot be effectively used for recovering the liver functions in acute hepatotoxicity tests using and t-BHP. Further researches, for example treated long period, must be tried to verify the efficacies.http://dx.doi.org/10.3831/KPI.2007.10.1.101Cultivated GinsengCultivated Wild GinsengCCl4hepatotoxicity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kim, Young-Jin Park, Hee-Soo Kwon, Ki-Rok Kim, Ho-Hyun |
spellingShingle |
Kim, Young-Jin Park, Hee-Soo Kwon, Ki-Rok Kim, Ho-Hyun Protective Effects of Cultivated Ginseng, Cultivated Wild Ginseng of Korean and Chinese Against CCl4 and t-BHP Induced Acute Hepatotoxicity in ICR Mice Journal of Pharmacopuncture Cultivated Ginseng Cultivated Wild Ginseng CCl4 hepatotoxicity |
author_facet |
Kim, Young-Jin Park, Hee-Soo Kwon, Ki-Rok Kim, Ho-Hyun |
author_sort |
Kim, Young-Jin |
title |
Protective Effects of Cultivated Ginseng, Cultivated Wild Ginseng of Korean and Chinese Against CCl4 and t-BHP Induced Acute Hepatotoxicity in ICR Mice |
title_short |
Protective Effects of Cultivated Ginseng, Cultivated Wild Ginseng of Korean and Chinese Against CCl4 and t-BHP Induced Acute Hepatotoxicity in ICR Mice |
title_full |
Protective Effects of Cultivated Ginseng, Cultivated Wild Ginseng of Korean and Chinese Against CCl4 and t-BHP Induced Acute Hepatotoxicity in ICR Mice |
title_fullStr |
Protective Effects of Cultivated Ginseng, Cultivated Wild Ginseng of Korean and Chinese Against CCl4 and t-BHP Induced Acute Hepatotoxicity in ICR Mice |
title_full_unstemmed |
Protective Effects of Cultivated Ginseng, Cultivated Wild Ginseng of Korean and Chinese Against CCl4 and t-BHP Induced Acute Hepatotoxicity in ICR Mice |
title_sort |
protective effects of cultivated ginseng, cultivated wild ginseng of korean and chinese against ccl4 and t-bhp induced acute hepatotoxicity in icr mice |
publisher |
Korean Pharmacopuncture Institute |
series |
Journal of Pharmacopuncture |
issn |
2093-6966 2234-6856 |
publishDate |
2007-02-01 |
description |
Objectives : This study was aimed at investigating live protection mechanism of Cultivated Ginseng and Cultivated Wild Ginseng of Korean and Chinese by inducing liver toxicity through and t-BHP in mice and evaluated serological findings.
Methods : Experiment groups was categorized into untreated normal group, treated control group, and orally administered Cultivated Ginseng and Cultivated Wild Ginseng of Korean and Chinese experimental groups. At the termination of experiment, gross examination of the liver as well as Total bilirubin, AST, and ALT contents in the serum were evaluated.
Results : 1. In the induced acute hepatotoxicity test, total bilirubin, AST and ALT didn't show significant differences between the control and experimental groups.
2. In the t-BHP induced acute hepatotoxicity test, total bilirubin, AST and ALT didn't show significant differences between the control and experimental groups. Conclusion : Taken together, Cultivated Ginseng and Cultivated Wild Ginseng of Korean and Chinese cannot be effectively used for recovering the liver functions in acute hepatotoxicity tests using and t-BHP. Further researches, for example treated long period, must be tried to verify the efficacies. |
topic |
Cultivated Ginseng Cultivated Wild Ginseng CCl4 hepatotoxicity |
url |
http://dx.doi.org/10.3831/KPI.2007.10.1.101 |
work_keys_str_mv |
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