Rac1 deletion causes thymic atrophy.

The thymic stroma supports T lymphocyte development and consists of an epithelium maintained by thymic epithelial progenitors. The molecular pathways that govern epithelial homeostasis are poorly understood. Here we demonstrate that deletion of Rac1 in Keratin 5/Keratin 14 expressing embryonic and a...

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Bibliographic Details
Main Authors: Lukas Hunziker, Salvador Aznar Benitah, Kristin M Braun, Kim Jensen, Katrina McNulty, Colin Butler, Elspeth Potton, Emma Nye, Richard Boyd, Geoff Laurent, Michael Glogauer, Nick A Wright, Fiona M Watt, Sam M Janes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3084817?pdf=render