Functional Assays for Measuring the Catalytic Activity of Ribosome Inactivating Proteins

Functional Assays for Measuring the Catalytic Activity of Ribosome Inactivating Proteins

Ribosome-inactivating proteins (RIPs) are potent toxins that inactivate ribosomes by catalytically removing a specific adenine from the α-sarcin/ricin loop (SRL) of the large rRNA. Direct assays for measuring depurination activity and indirect assays for measuring the resulting translation...

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Bibliographic Details
Main Authors: Yijun Zhou, Xiao-Ping Li, Jennifer N. Kahn, Nilgun E. Tumer
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Toxins
Subjects:
ribosome inactivating protein
depurination assays
translation inhibition assays
Online Access:http://www.mdpi.com/2072-6651/10/6/240

Internet

http://www.mdpi.com/2072-6651/10/6/240

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