5-Bis-(2,6-difluoro-benzylidene) Cyclopentanone Acts as a Selective 11β-Hydroxysteroid Dehydrogenase one Inhibitor to Treat Diet-Induced Nonalcoholic Fatty Liver Disease in Mice

5-Bis-(2,6-difluoro-benzylidene) Cyclopentanone Acts as a Selective 11β-Hydroxysteroid Dehydrogenase one Inhibitor to Treat Diet-Induced Nonalcoholic Fatty Liver Disease in Mice

Background: 11β-Hydroxysteroid dehydrogenase one is responsible for activating inert glucocorticoid cortisone into biologically active cortisol in humans and may be a novel target for the treatment of nonalcoholic fatty liver disease.Methods: A series of benzylidene cyclopentanone derivatives were s...

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Bibliographic Details
Main Authors: Hongguo Guan, Yiyan Wang, Huitao Li, Qiqi Zhu, Xiaoheng Li, Guang Liang, Ren-Shan Ge
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
11b-hydroxysteroid dehydrogenase 2
11b-hydroxysteroid dehydrogenase 1 inhibitor
cyclopentanone derivatives
nonalcoholic fatty liver disease
insulin resisitance
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.594437/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.594437/full

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