A Novel Gene Delivery Vector of Agonistic Anti-Radioprotective 105 Expressed on Cell Membranes Shows Adjuvant Effect for DNA Immunization Against Influenza

A Novel Gene Delivery Vector of Agonistic Anti-Radioprotective 105 Expressed on Cell Membranes Shows Adjuvant Effect for DNA Immunization Against Influenza

Radioprotective 105 (RP105) (also termed CD180) is an orphan and unconventional Toll-like receptor (TLR) that lacks an intracellular signaling domain. The agonistic anti-RP105 monoclonal antibody (mAb) can cross-link RP105 on B cells, resulting in the proliferation and activation of B cells. Anti-RP...

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Bibliographic Details
Main Authors: Tatsuya Yamazaki, Mrityunjoy Biswas, Kouyu Kosugi, Maria Nagashima, Masanori Inui, Susumu Tomono, Hidekazu Takagi, Isao Ichimonji, Fumiaki Nagaoka, Akira Ainai, Hideki Hasegawa, Joe Chiba, Sachiko Akashi-Takamura
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
antibody gene-vector delivery
adjuvant
RP105
DNA immunization
agonistic antibody
targeting antigen to B cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.606518/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.606518/full

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