CYCLODEXTRINS - FIELFS OF APPLICATION. PART II

This paper represents an analysis of potential and current applications of cyclodextrins as biologically active substances in medicine. The main applications described here include use of cyclodextrins as agents that form inclusion complexes with endogenous substances (membrane lipids, cellular c...

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Bibliographic Details
Main Authors: Gh. Duca, A. Ivancic, V. Boldescu
Format: Article
Language:English
Published: Academy of Sciences of Moldova, Institute of Chemistry 2012-12-01
Series:Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry
Subjects:
Online Access:http://www.cjm.asm.md/sites/default/files/article_files/Duca%2039-45.pdf
Description
Summary:This paper represents an analysis of potential and current applications of cyclodextrins as biologically active substances in medicine. The main applications described here include use of cyclodextrins as agents that form inclusion complexes with endogenous substances (membrane lipids, cellular cholesterol), agents that form inclusion complexes with exogenous substances with their man role as guest molecules (sugammadex, FBCx), agents that block endogenous and exogenous macromolecules (ion channels, anthrax toxin, α-hemolysin), and agents which activity is based on the chemical nature of them and of their derivatives (cyclodextrin polysulphate derivatives). The fi rst classifi cation for medically important biological activity of cyclodextrins has been proposed.
ISSN:1857-1727
2345-1688