Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotype.

Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotype.

Methylation of specific lysine residues in core histone proteins is essential for embryonic development and can impart active and inactive epigenetic marks on chromatin domains. The ubiquitous nuclear protein PTIP is encoded by the Paxip1 gene and is an essential component of a histone H3 lysine 4 (...

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Bibliographic Details
Main Authors: Gaelle M Lefevre, Sanjeevkumar R Patel, Doyeob Kim, Lino Tessarollo, Gregory R Dressler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2965754?pdf=render

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http://europepmc.org/articles/PMC2965754?pdf=render

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