Lysophosphatidic Acid Is Associated with Atherosclerotic Plaque Instability by Regulating NF-κB Dependent Matrix Metalloproteinase-9 Expression via LPA2 in Macrophages

Lysophosphatidic Acid Is Associated with Atherosclerotic Plaque Instability by Regulating NF-κB Dependent Matrix Metalloproteinase-9 Expression via LPA2 in Macrophages

Lysophosphatidic acid (LPA), one of the simplest phospholipid signaling molecules, participates in formation and disruption of atherosclerotic plaque. Matrix metalloproteinases (MMPs) contribute to atherosclerotic plaque rupture by involving in extracellular matrix (ECM) degradation and then thinnin...

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Bibliographic Details
Main Authors: Xi Chen, Chun Gu, Fang Wang, Zhenwen Zhao, Hongyue Wang, Xiangfeng Cong
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Physiology
Subjects:
lysophosphatidic acid
matrix metalloproteinase-9
macrophages
LPA2
coronary atherosclerotic plaques
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00266/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00266/full

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