In cancer cell lines inhibition of SCF/c-Kit pathway leads to radiosensitization only when SCF is strongly over-expressed

In cancer cell lines inhibition of SCF/c-Kit pathway leads to radiosensitization only when SCF is strongly over-expressed

Background and purpose: The SCF/c-Kit pathway is often overexpressed in human tumors leading to an enhanced tumorigenesis, proliferation and migration. It was now tested for NSCLC and prostate cancer cells growing in 2D and 3D whether the inhibition of this pathway can be used to achieve a significa...

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Bibliographic Details
Main Authors: Fabian Eberle, Florian H. Leinberger, Miriam F. Saulich, Werner Seeger, Rita Engenhart-Cabillic, Jörg Hänze, Katja Hattar, Ekkehard Dikomey, Florentine S.B. Subtil
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Clinical and Translational Radiation Oncology
Subjects:
X-irradiation
NSCLC
Clonogenic survival
3D cell culture
SCF/c-Kit pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2405630816300106

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http://www.sciencedirect.com/science/article/pii/S2405630816300106

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