TCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention program.

TCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention program.

TCF7L2 variants have been associated with type 2 diabetes, body mass index (BMI), and deficits in proinsulin processing and insulin secretion. Here we sought to test whether these effects were apparent in high-risk individuals and modify treatment responses.We examined the potential role of the TCF7...

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Bibliographic Details
Main Authors: Jeanne M McCaffery, Kathleen A Jablonski, Paul W Franks, Sam Dagogo-Jack, Rena R Wing, William C Knowler, Linda Delahanty, Dana Dabelea, Richard Hamman, Alan R Shuldiner, Jose C Florez, Diabetes Prevention Program Research Group
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3144193?pdf=render

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http://europepmc.org/articles/PMC3144193?pdf=render

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