Correlation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and type 2 diabetic retinopathy

• Main Authors: Pei-Pei Wu, Xiao Lu, Qing-Jing Wu, Cai-Xia Liu, Yun-Fei Chen, Qing Xie
• Format: Article
• Language: English
• Published: Press of International Journal of Ophthalmology (IJO PRESS) 2019-07-01
• Series: Guoji Yanke Zazhi
• Subjects: type 2 diabetes mellitus; diabetic retinopathy; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio
• Online Access: http://ies.ijo.cn/cn_publish/2019/7/201907003.pdf
• ISSN: 1672-5123; 1672-5123

AIM: To investigate the relationship between neutrophil-to-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR)and type 2 diabetic retinopathy(DR).<p>METHODS:A total of 200 cases with type 2 diabetes mellitus were involved. All patients were divided into three groups according to the fundus examination: diabetes mellitus(DM, <i>n</i>=100), non-proliferative diabetic retinopathy(NPDR, <i>n</i>=62)and proliferative diabetic retinopathy(PDR, <i>n</i>=38). 100 healthy persons were selected as the normal control group(NCG, <i>n</i>=100). The related indicators, such as neutrophil count, lymphocyte count and platelet count were measured. <p>RESULTS: The value of NLR was significantly higher in PDR group patients than in NC group(1.81), DM group(1.76)and NPDR group(1.85)(<i>P</i><0.05). The value of PLR was significantly higher in PDR group patients(126.18)than in DM group(111.64)(<i>P</i><0.05). Logistic regression analysis showed that age(β= -0.047)was protective factor, course of diabetes(β=0.071)and systolic blood pressure(β=0.024)were risk factors for diabetic retinopathy(<i>P</i><0.05), but the value of NLR and PLR was not statistically significant in the Logistic regression analysis. <p>CONCLUSION: The value of NLR and PLR increased in the PDR group, but it is not independent risk factor for diabetic retinopathy.