Dynamic Flowsheet Model Development and Sensitivity Analysis of a Continuous Pharmaceutical Tablet Manufacturing Process Using the Wet Granulation Route

Dynamic Flowsheet Model Development and Sensitivity Analysis of a Continuous Pharmaceutical Tablet Manufacturing Process Using the Wet Granulation Route

In view of growing interest and investment in continuous manufacturing, the development and utilization of mathematical model(s) of the manufacturing line is of prime importance. These models are essential for understanding the complex interplay between process-wide critical process parameters (CPPs...

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Bibliographic Details
Main Authors: Nirupaplava Metta, Michael Ghijs, Elisabeth Schäfer, Ashish Kumar, Philippe Cappuyns, Ivo Van Assche, Ravendra Singh, Rohit Ramachandran, Thomas De Beer, Marianthi Ierapetritou, Ingmar Nopens
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Processes
Subjects:
model integration
flowsheet modeling
sensitivity analysis
continuous manufacturing
wet granulation
Online Access:https://www.mdpi.com/2227-9717/7/4/234

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https://www.mdpi.com/2227-9717/7/4/234

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