In vitro inhibition and reversal of Plasmodium falciparum cytoadherence to endothelium by monoclonal antibodies to ICAM-1 and CD36

In vitro inhibition and reversal of Plasmodium falciparum cytoadherence to endothelium by monoclonal antibodies to ICAM-1 and CD36

Abstract Background Sequestration of parasitized red blood cells from the peripheral circulation during an infection with Plasmodium falciparum is caused by an interaction between the parasite protein PfEMP1 and receptors on the surface of host endothelial cells, known as cytoadherence. Several line...

Full description

Bibliographic Details
Main Authors: Khairul M. F. Mustaffa, Janet Storm, Megan Whittaker, Tadge Szestak, Alister G. Craig
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Malaria Journal
Subjects:
Plasmodium falciparum
Monoclonal antibody
Adjunct therapy
Severe malaria
Cytoadherence
Reversal
Online Access:http://link.springer.com/article/10.1186/s12936-017-1930-9

Internet

http://link.springer.com/article/10.1186/s12936-017-1930-9

Similar Items