The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

Previously, we identified ISRIB as a potent inhibitor of the integrated stress response (ISR) and showed that ISRIB makes cells resistant to the effects of eIF2α phosphorylation and enhances long-term memory in rodents (Sidrauski et al., 2013). Here, we show by genome-wide in vivo ribosome profiling...

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Bibliographic Details
Main Authors: Carmela Sidrauski, Anna M McGeachy, Nicholas T Ingolia, Peter Walter
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-02-01
Series:eLife
Subjects:
integrated stress response
eIF2
unfolded protein response
ISRIB
protein synthesis
ribosome profiling
Online Access:https://elifesciences.org/articles/05033

Internet

https://elifesciences.org/articles/05033

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