Highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysis

Highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysis

Biocatalysis can perform highly selective multi-step synthesis in one pot, but with a limited range of non-natural reactions and products. Here, the authors report regio- and enantioselective bio-cascades, able to convert styrenes into a number of nitrogen and oxygen containing chiral molecules.

Bibliographic Details
Main Authors: Shuke Wu, Yi Zhou, Tianwen Wang, Heng-Phon Too, Daniel I. C. Wang, Zhi Li
Format: Article
Language:English
Published: Nature Publishing Group 2016-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11917
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spelling doaj-36f03d68691543e08916d8c32551a6b42021-05-11T11:14:12ZengNature Publishing GroupNature Communications2041-17232016-06-017111310.1038/ncomms11917Highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysisShuke Wu0Yi Zhou1Tianwen Wang2Heng-Phon Too3Daniel I. C. Wang4Zhi Li5Department of Chemical and Biomolecular Engineering, National University of SingaporeSynthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute, National University of SingaporeDepartment of Chemical and Biomolecular Engineering, National University of SingaporeSingapore-MIT Alliance, National University of SingaporeSingapore-MIT Alliance, National University of SingaporeDepartment of Chemical and Biomolecular Engineering, National University of SingaporeBiocatalysis can perform highly selective multi-step synthesis in one pot, but with a limited range of non-natural reactions and products. Here, the authors report regio- and enantioselective bio-cascades, able to convert styrenes into a number of nitrogen and oxygen containing chiral molecules.https://doi.org/10.1038/ncomms11917
collection DOAJ
language English
format Article
sources DOAJ
author Shuke Wu
Yi Zhou
Tianwen Wang
Heng-Phon Too
Daniel I. C. Wang
Zhi Li
spellingShingle Shuke Wu
Yi Zhou
Tianwen Wang
Heng-Phon Too
Daniel I. C. Wang
Zhi Li
Highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysis
Nature Communications
author_facet Shuke Wu
Yi Zhou
Tianwen Wang
Heng-Phon Too
Daniel I. C. Wang
Zhi Li
author_sort Shuke Wu
title Highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysis
title_short Highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysis
title_full Highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysis
title_fullStr Highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysis
title_full_unstemmed Highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysis
title_sort highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-06-01
description Biocatalysis can perform highly selective multi-step synthesis in one pot, but with a limited range of non-natural reactions and products. Here, the authors report regio- and enantioselective bio-cascades, able to convert styrenes into a number of nitrogen and oxygen containing chiral molecules.
url https://doi.org/10.1038/ncomms11917
work_keys_str_mv AT shukewu highlyregioandenantioselectivemultipleoxyandaminofunctionalizationsofalkenesbymodularcascadebiocatalysis
AT yizhou highlyregioandenantioselectivemultipleoxyandaminofunctionalizationsofalkenesbymodularcascadebiocatalysis
AT tianwenwang highlyregioandenantioselectivemultipleoxyandaminofunctionalizationsofalkenesbymodularcascadebiocatalysis
AT hengphontoo highlyregioandenantioselectivemultipleoxyandaminofunctionalizationsofalkenesbymodularcascadebiocatalysis
AT danielicwang highlyregioandenantioselectivemultipleoxyandaminofunctionalizationsofalkenesbymodularcascadebiocatalysis
AT zhili highlyregioandenantioselectivemultipleoxyandaminofunctionalizationsofalkenesbymodularcascadebiocatalysis
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