Wound Healing Activity of a New Formulation from Platelet Lysate

• Main Authors: Akram Jamshidzadeh, Omid Koohi Hosseinabadi, Reza Heidari, Soliman Mohammadi-Samani, Sara Rajabzadeh, Seyed Mojtaba Seyed Raoufi, Alireza Ahmadi Vadeghani
• Format: Article
• Language: English
• Published: Shiraz University of Medical Sciences 2016-03-01
• Series: Trends in Pharmaceutical Sciences
• Subjects: Gel-based new formulation; Growth factors; Platelet-rich plasma; Regenerative medicine
• Online Access: http://tips.sums.ac.ir/index.php/TiPS/article/view/61/67

Platelet-rich plasma (PRP) is an attractive preparation in regenerative medicine due to its potential role in the healing process in different experimental models. This study was designed to investigate the wound healing activity of a new formulation of PRP. Different gel-based formulations of PRP were prepared. Open excision wounds were made on the back of male Sprague-Dawley rats, and PRP gel was administered topically once daily until the wounds healed completely (12 days). The results revealed that the tested PRP formulation significantly accelerated the wound healing process by increasing the wound contraction, tissue granulization, vascularization, and collagen regeneration. Interestingly, this study showed that there were no significant differences between the PRP and its gel-based formulation in all the above mentioned parameters. Although this investigation showed that PRP formulation had significant wound healing effects, the PRP gel-based formulation also had significant wound healing properties. This might indicate the wound healing properties of the PRP gel ingredients in the current investigation.