Platelet transcriptome profiles provide potential therapeutic targets for elderly acute myelocytic leukemia patients

Platelet transcriptome profiles provide potential therapeutic targets for elderly acute myelocytic leukemia patients

Highlights 1. Gene transcript profiles in the elderly AML patients are different from those in young patients. 2. Statistical analysis reveals the down-regulation of protein processing in ER and pathways related to immunity in elderly patients. 3. GEO and GSEA analyses demonstrate the genes of cance...

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Bibliographic Details
Main Authors: Jizhang Bao, Xinhua Zhao, Jiahui Lu, Zhaoyang Hu, Minghui Hu, Xiaoxia Hu, Libing Wang, Qi Hu, Weiling Sun, Jie Wang, Hailin Chen, Hao Lu, Changgui Li, Jing Xu, Yongming Zhou, Wenwei Zhu
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Translational Medicine
Subjects:
Acute myeloid leukemia
Platelet RNA sequencing
Mitogen activated protein kinase
Activating transcription factor 4
Online Access:https://doi.org/10.1186/s12967-021-03041-8

Internet

https://doi.org/10.1186/s12967-021-03041-8

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