Drivers and sites of diversity in the DNA adenine methylomes of 93 Mycobacterium tuberculosis complex clinical isolates

Drivers and sites of diversity in the DNA adenine methylomes of 93 Mycobacterium tuberculosis complex clinical isolates

This study assembles DNA adenine methylomes for 93 Mycobacterium tuberculosis complex (MTBC) isolates from seven lineages paired with fully-annotated, finished, de novo assembled genomes. Integrative analysis yielded four key results. First, methyltransferase allele-methylome mapping corrected methy...

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Bibliographic Details
Main Authors: Samuel J Modlin, Derek Conkle-Gutierrez, Calvin Kim, Scott N Mitchell, Christopher Morrissey, Brian C Weinrick, William R Jacobs, Sarah M Ramirez-Busby, Sven E Hoffner, Faramarz Valafar
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
tuberculosis
dna methylation
phenotypic plasticity
epigenetic
intracellular stochastic methylation
intercellular mosaic methylation
Online Access:https://elifesciences.org/articles/58542

Internet

https://elifesciences.org/articles/58542

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