Heterologous expression of Mus musculus immunoresponsive gene 1 (irg1) in Escherichia coli results in itaconate production

Heterologous expression of Mus musculus immunoresponsive gene 1 (irg1) in Escherichia coli results in itaconate production

Itaconic acid, a C5-dicarboxylic acid, is a potential biobased building block for the polymer industry. It is obtained from the citric acid cycle by decarboxylation of cis-aconitic acid. This reaction is catalysed by CadA in the native itaconic acid producer Aspergillus terreus. Recently, another en...

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Bibliographic Details
Main Authors: Kiira S Vuoristo, Astrid E Mars, Stijn van eLoon, Enrico eOrsi, Gerrit eEggink, Johan P.M. Sanders, Ruud A Weusthuis
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Microbiology
Subjects:
Escherichia coli
Metabolic Engineering
Itaconic acid
cis-Aconitate decarboxylase
codon optimization
Codon harmonization
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00849/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00849/full

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