Rescue of Metabolic Alterations in AR113Q Skeletal Muscle by Peripheral Androgen Receptor Gene Silencing

Rescue of Metabolic Alterations in AR113Q Skeletal Muscle by Peripheral Androgen Receptor Gene Silencing

Spinal and bulbar muscular atrophy (SBMA), a progressive degenerative disorder, is caused by a CAG/glutamine expansion in the androgen receptor (polyQ AR). Recent studies demonstrate that skeletal muscle is an important site of toxicity that contributes to the SBMA phenotype. Here, we sought to iden...

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Bibliographic Details
Main Authors: Elisa Giorgetti, Zhigang Yu, Jason P. Chua, Ryosuke Shimamura, Lili Zhao, Fan Zhu, Sriram Venneti, Maria Pennuto, Yuanfang Guan, Gene Hung, Andrew P. Lieberman
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Cell Reports
Subjects:
CAG/polyglutamine disease
spinal and bulbar muscular atrophy
antisense oligonucleotides
skeletal muscle
metabolism
glycolysis
mitochondria
exercise
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716311809

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http://www.sciencedirect.com/science/article/pii/S2211124716311809

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