In Silico Simulation of the Systemic Drug Exposure Following the Topical Application of Opioid Analgesics in Patients with Cutaneous Lesions

In Silico Simulation of the Systemic Drug Exposure Following the Topical Application of Opioid Analgesics in Patients with Cutaneous Lesions

The use of opioid analgesics in treating severe pain is frequently associated with putative adverse effects in humans. Topical agents that are shown to have high efficacy with a favorable safety profile in clinical settings are great alternatives for pain management of multimodal analgesia. However,...

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Bibliographic Details
Main Authors: Maksim Khotimchenko, Victor Antontsev, Kaushik Chakravarty, Hypatia Hou, Jyotika Varshney
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Pharmaceutics
Subjects:
computational modeling
opioid analgesics
transdermal
pharmacokinetics
Online Access:https://www.mdpi.com/1999-4923/13/2/284

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