UVB induces a genome-wide acting negative regulatory mechanism that operates at the level of transcription initiation in human cells.
Faithful transcription of DNA is constantly threatened by different endogenous and environmental genotoxic effects. Transcription coupled repair (TCR) has been described to stop transcription and quickly remove DNA lesions from the transcribed strand of active genes, permitting rapid resumption of b...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-07-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC4109906?pdf=render |