Mutant human torsinA, responsible for early-onset dystonia, dominantly suppresses GTPCH expression, dopamine levels and locomotion in Drosophila melanogaster

Mutant human torsinA, responsible for early-onset dystonia, dominantly suppresses GTPCH expression, dopamine levels and locomotion in Drosophila melanogaster

Dystonia represents the third most common movement disorder in humans with over 20 genetic loci identified. TOR1A (DYT1), the gene responsible for the most common primary hereditary dystonia, encodes torsinA, an AAA ATPase family protein. Most cases of DYT1 dystonia are caused by a 3 bp (ΔGAG) delet...

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Bibliographic Details
Main Authors: Noriko Wakabayashi-Ito, Rami R. Ajjuri, Benjamin W. Henderson, Olugbenga M. Doherty, Xandra O. Breakefield, Janis M. O'Donnell, Naoto Ito
Format: Article
Language:English
Published: The Company of Biologists 2015-07-01
Series:Biology Open
Subjects:
Dystonia
Drosophila
GTP cyclohydrolase
TorsinA
Movement disorder
Online Access:http://bio.biologists.org/content/4/5/585

Internet

http://bio.biologists.org/content/4/5/585

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