Methodological Assessment of Case–Crossover Studies

The case-crossover design was developed in the early 1990s to study the effects of transient, short-term exposures on the risk of acute events such as myocardial infarction. To estimate relative risk, the exposure frequency during a period just before outcome onset (hazard period) is compared with...

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Main Authors: M Qorbani, M Yunesian
Format: Article
Language:fas
Published: Tehran University of Medical Sciences 2008-04-01
Series:مجله اپیدمیولوژی ایران
Subjects:
Online Access:http://irje.tums.ac.ir/browse.php?a_code=A-10-25-154&slc_lang=en&sid=1
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spelling doaj-395ac36845864cecbe61383002de81962021-09-02T21:00:48ZfasTehran University of Medical Sciencesمجله اپیدمیولوژی ایران1735-74892228-75072008-04-01415969Methodological Assessment of Case–Crossover StudiesM Qorbani0M Yunesian1 The case-crossover design was developed in the early 1990s to study the effects of transient, short-term exposures on the risk of acute events such as myocardial infarction. To estimate relative risk, the exposure frequency during a period just before outcome onset (hazard period) is compared with exposure frequency during control time(s) in that person rather than in a control. One or more "control times" are supplied by each of the cases themselves to control for confounding by constant characteristics and self-confounding between the trigger's acute and chronic effects. In the analysis of case-crossover studies, exposure frequency in the hazard period is compared with the control period or the individual's usual frequency of exposure. The design has been used frequently for heart diseases, injuries and air pollution epidemiology. This review article looks at published case-crossover studies and is intended to help the reader gain a better understanding of the strengths and limitations of the case-crossover design in studying the epidemiology of injuries and air pollution. http://irje.tums.ac.ir/browse.php?a_code=A-10-25-154&slc_lang=en&sid=1Case-crossoverMatched case-controlCrossover
collection DOAJ
language fas
format Article
sources DOAJ
author M Qorbani
M Yunesian
spellingShingle M Qorbani
M Yunesian
Methodological Assessment of Case–Crossover Studies
مجله اپیدمیولوژی ایران
Case-crossover
Matched case-control
Crossover
author_facet M Qorbani
M Yunesian
author_sort M Qorbani
title Methodological Assessment of Case–Crossover Studies
title_short Methodological Assessment of Case–Crossover Studies
title_full Methodological Assessment of Case–Crossover Studies
title_fullStr Methodological Assessment of Case–Crossover Studies
title_full_unstemmed Methodological Assessment of Case–Crossover Studies
title_sort methodological assessment of case–crossover studies
publisher Tehran University of Medical Sciences
series مجله اپیدمیولوژی ایران
issn 1735-7489
2228-7507
publishDate 2008-04-01
description The case-crossover design was developed in the early 1990s to study the effects of transient, short-term exposures on the risk of acute events such as myocardial infarction. To estimate relative risk, the exposure frequency during a period just before outcome onset (hazard period) is compared with exposure frequency during control time(s) in that person rather than in a control. One or more "control times" are supplied by each of the cases themselves to control for confounding by constant characteristics and self-confounding between the trigger's acute and chronic effects. In the analysis of case-crossover studies, exposure frequency in the hazard period is compared with the control period or the individual's usual frequency of exposure. The design has been used frequently for heart diseases, injuries and air pollution epidemiology. This review article looks at published case-crossover studies and is intended to help the reader gain a better understanding of the strengths and limitations of the case-crossover design in studying the epidemiology of injuries and air pollution.
topic Case-crossover
Matched case-control
Crossover
url http://irje.tums.ac.ir/browse.php?a_code=A-10-25-154&slc_lang=en&sid=1
work_keys_str_mv AT mqorbani methodologicalassessmentofcasecrossoverstudies
AT myunesian methodologicalassessmentofcasecrossoverstudies
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