Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity

Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity

Infection with the food-borne liver fluke Opisthorchis viverrini is the principal risk factor (IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2012) for cholangiocarcinoma (CCA) in the Lower Mekong River Basin countries including Thailand, Lao PDR, Vietnam and Cambodia. We expl...

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Bibliographic Details
Main Authors: Patpicha Arunsan, Wannaporn Ittiprasert, Michael J Smout, Christina J Cochran, Victoria H Mann, Sujittra Chaiyadet, Shannon E Karinshak, Banchob Sripa, Neil David Young, Javier Sotillo, Alex Loukas, Paul J Brindley, Thewarach Laha
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
Opisthorchis viverrini
gene-editing
carcinogenic
Online Access:https://elifesciences.org/articles/41463

Internet

https://elifesciences.org/articles/41463

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