Mitochondrial CMPK2 mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways

Mitochondrial CMPK2 mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways

Summary: Mitochondria regulate the immune response after dengue virus (DENV) infection. Microarray analysis of genes identified the upregulation of mitochondrial cytidine/uridine monophosphate kinase 2 (CMPK2) by DENV infection. We used small interfering RNA-mediated knockdown (KD) and CRISPR-Cas9 k...

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Bibliographic Details
Main Authors: Jenn-Haung Lai, De-Wei Wu, Chien-Hsiang Wu, Li-Feng Hung, Chuan-Yueh Huang, Shuk-Man Ka, Ann Chen, Zee-Fen Chang, Ling-Jun Ho
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:iScience
Subjects:
Molecular biology
Immunology
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221004661

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http://www.sciencedirect.com/science/article/pii/S2589004221004661

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