Melatonin suppresses ER stress-dependent proapoptotic effects via AMPK in bone mesenchymal stem cells during mitochondrial oxidative damage

Melatonin suppresses ER stress-dependent proapoptotic effects via AMPK in bone mesenchymal stem cells during mitochondrial oxidative damage

Abstract Background Bone marrow mesenchymal stem cells (BMSCs) have been used as important cell-based tools for clinical applications. Oxidative stress-induced apoptosis causes a low survival rate after transplantation, and the underlying mechanisms remain unknown. The endoplasmic reticulum (ER) and...

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Bibliographic Details
Main Authors: Chongxi Fan, Jianyu Feng, Chi Tang, Zhengbin Zhang, Yingtong Feng, Weixun Duan, Mingming Zhai, Zedong Yan, Liwen Zhu, Lele Feng, Hanzhao Zhu, Erping Luo
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Stem Cell Research & Therapy
Subjects:
Melatonin
Bone marrow mesenchymal stem cells
ER stress
AMPK
Oxidative stress
Online Access:http://link.springer.com/article/10.1186/s13287-020-01948-5

Internet

http://link.springer.com/article/10.1186/s13287-020-01948-5

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