Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis

Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis

Background: During atherogenesis, cholesterol precipitates into cholesterol crystals (CC) in the vessel wall, which trigger plaque inflammation by activating the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome. We investigated the relationship between CC, complement and NLRP3 in...

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Bibliographic Details
Main Authors: Nathalie Niyonzima, Siril S. Bakke, Ida Gregersen, Sverre Holm, Øystein Sandanger, Hilde L. Orrem, Bjørnar Sporsheim, Liv Ryan, Xiang Yi Kong, Tuva Børresdatter Dahl, Mona Skjelland, Kirsten Krohg Sørensen, Anne Mari Rokstad, Arne Yndestad, Eicke Latz, Lars Gullestad, Geir Ø. Andersen, Jan Kristian Damås, Pål Aukrust, Tom E. Mollnes, Bente Halvorsen, Terje Espevik
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:EBioMedicine
Subjects:
Cholesterol crystals
Complement system
NLRP3 inflammasome
Coronary artery disease
Carotid atherosclerosis
Atherosclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420303613

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