Lisinopril-Induced Liver Injury: An Unusual Presentation and Literature Review
Lisinopril is an angiotensin converting enzyme inhibitor (ACE-I) that has been on market for more than 25 years. ACE-I are usually well tolerated and rarely have serious or life-threatening side effects. We describe an unusual presentation of fulminant hepatic cholestasis probably secondary to lisin...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
SMC MEDIA SRL
2020-04-01
|
Series: | European Journal of Case Reports in Internal Medicine |
Subjects: | |
Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/1600 |
id |
doaj-39ccdc4bbafb45a3a022d47047d8fdf4 |
---|---|
record_format |
Article |
spelling |
doaj-39ccdc4bbafb45a3a022d47047d8fdf42020-11-25T03:15:49ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942020-04-0110.12890/2020_0016001242Lisinopril-Induced Liver Injury: An Unusual Presentation and Literature ReviewAmmar Al-Rifaie0Mir Azam Khan1Amjad Ali2Asha Kumari Dube3Dermot Gleeson4Barbara Hoeroldt5Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UKSheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UKSheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UKSheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UKSheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UKSheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UKLisinopril is an angiotensin converting enzyme inhibitor (ACE-I) that has been on market for more than 25 years. ACE-I are usually well tolerated and rarely have serious or life-threatening side effects. We describe an unusual presentation of fulminant hepatic cholestasis probably secondary to lisinopril. To our knowledge, this is the second case report which shows lisinopril-induced liver injury though a cholestatic mechanism. The patient was a 59-year-old woman with type 2 diabetes, a high body mass index and hypertension, who presented with a 5-week history of jaundice and itching. She had been started on lisinopril for diabetic nephropathy 8 weeks before admission. Other causes for cholestasis had been excluded through non-invasive immunology and virology screening, an ultrasound of the liver, magnetic resonance cholangiopancreatography and a liver biopsy. The biopsy was consistent with drug-induced liver injury. Lisinopril was stopped 2 weeks before admission. The patient’s hospital stay was complicated by contrast nephropathy and influenza A which were both treated appropriately. Unfortunately, the liver cholestasis did not completely resolve following withdrawal of lisinopril and the patient died after 4 months. A literature search yielded only six other reported cases of lisinopril-induced liver injury. Five cases described hepatocellular damage and one showed cholestatic injury.https://www.ejcrim.com/index.php/EJCRIM/article/view/1600angiotensin converting enzyme inhibitorslisinoprildrug-induced liver injurycholestasis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ammar Al-Rifaie Mir Azam Khan Amjad Ali Asha Kumari Dube Dermot Gleeson Barbara Hoeroldt |
spellingShingle |
Ammar Al-Rifaie Mir Azam Khan Amjad Ali Asha Kumari Dube Dermot Gleeson Barbara Hoeroldt Lisinopril-Induced Liver Injury: An Unusual Presentation and Literature Review European Journal of Case Reports in Internal Medicine angiotensin converting enzyme inhibitors lisinopril drug-induced liver injury cholestasis |
author_facet |
Ammar Al-Rifaie Mir Azam Khan Amjad Ali Asha Kumari Dube Dermot Gleeson Barbara Hoeroldt |
author_sort |
Ammar Al-Rifaie |
title |
Lisinopril-Induced Liver Injury: An Unusual Presentation and Literature Review |
title_short |
Lisinopril-Induced Liver Injury: An Unusual Presentation and Literature Review |
title_full |
Lisinopril-Induced Liver Injury: An Unusual Presentation and Literature Review |
title_fullStr |
Lisinopril-Induced Liver Injury: An Unusual Presentation and Literature Review |
title_full_unstemmed |
Lisinopril-Induced Liver Injury: An Unusual Presentation and Literature Review |
title_sort |
lisinopril-induced liver injury: an unusual presentation and literature review |
publisher |
SMC MEDIA SRL |
series |
European Journal of Case Reports in Internal Medicine |
issn |
2284-2594 |
publishDate |
2020-04-01 |
description |
Lisinopril is an angiotensin converting enzyme inhibitor (ACE-I) that has been on market for more than 25 years. ACE-I are usually well tolerated and rarely have serious or life-threatening side effects. We describe an unusual presentation of fulminant hepatic cholestasis probably secondary to lisinopril. To our knowledge, this is the second case report which shows lisinopril-induced liver injury though a cholestatic mechanism. The patient was a 59-year-old woman with type 2 diabetes, a high body mass index and hypertension, who presented with a 5-week history of jaundice and itching. She had been started on lisinopril for diabetic nephropathy 8 weeks before admission. Other causes for cholestasis had been excluded through non-invasive immunology and virology screening, an ultrasound of the liver, magnetic resonance cholangiopancreatography and a liver biopsy. The biopsy was consistent with drug-induced liver injury. Lisinopril was stopped 2 weeks before admission. The patient’s hospital stay was complicated by contrast nephropathy and influenza A which were both treated appropriately. Unfortunately, the liver cholestasis did not completely resolve following withdrawal of lisinopril and the patient died after 4 months. A literature search yielded only six other reported cases of lisinopril-induced liver injury. Five cases described hepatocellular damage and one showed cholestatic injury. |
topic |
angiotensin converting enzyme inhibitors lisinopril drug-induced liver injury cholestasis |
url |
https://www.ejcrim.com/index.php/EJCRIM/article/view/1600 |
work_keys_str_mv |
AT ammaralrifaie lisinoprilinducedliverinjuryanunusualpresentationandliteraturereview AT mirazamkhan lisinoprilinducedliverinjuryanunusualpresentationandliteraturereview AT amjadali lisinoprilinducedliverinjuryanunusualpresentationandliteraturereview AT ashakumaridube lisinoprilinducedliverinjuryanunusualpresentationandliteraturereview AT dermotgleeson lisinoprilinducedliverinjuryanunusualpresentationandliteraturereview AT barbarahoeroldt lisinoprilinducedliverinjuryanunusualpresentationandliteraturereview |
_version_ |
1724637322465509376 |