Reversal with sugammadex for rocuronium-induced deep neuromuscular block after pretreatment of magnesium sulfate in rabbits
BackgroundMagnesium sulfate (MgSO4) has been used in the treatment of pre-eclampsia, hypertension and arrhythmia. Magnesium enhances the neuromuscular block of rocuronium. This study has been conducted to evaluate the reversal efficacy of sugammadex from deep rocuronium-induced neuromuscular block (...
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doaj-3a0dd7ebc8da44158def16af202613cd2020-11-25T03:43:52ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632017-04-0170220320810.4097/kjae.2017.70.2.2038282Reversal with sugammadex for rocuronium-induced deep neuromuscular block after pretreatment of magnesium sulfate in rabbitsWoon Seok Kang0Kyo Sang Kim1Shin Mi Song2Department of Anesthesiology and Pain Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.Department of Anesthesiology and Pain Medicine, Hanyang University College of Medicine, Seoul, Korea.Department of Anesthesiology and Pain Medicine, Hanyang University College of Medicine, Seoul, Korea.BackgroundMagnesium sulfate (MgSO4) has been used in the treatment of pre-eclampsia, hypertension and arrhythmia. Magnesium enhances the neuromuscular block of rocuronium. This study has been conducted to evaluate the reversal efficacy of sugammadex from deep rocuronium-induced neuromuscular block (NMB) during consistent pretreatment of MgSO4 in rabbits.MethodsTwenty-eight rabbits were randomly assigned to four groups, a control group or study groups (50% MgSO4 150–200 mg/kg and 25 mg/kg/h IV), and received rocuronium 0.6 mg/kg. When post-tetanic count 1–2 appeared, sugammadex 2, 4, and 8 mg/kg was administered in the 2-mg group, control and 4-mg group, and 8-mg group, respectively. The recovery course after reversal of sugammadex administration was evaluated in each group.ResultsThe mean serum concentration of magnesium was maintained at more than 2 mmol/L in the study groups, and the total dose of MgSO4 was more than 590 mg. The reversal effect of sugammadex on rocuronium-induced NMB in pretreated MgSO4 was not different from that in the group without MgSO4. The recovery time to train-of-four ratio 0.9 after sugammadex administration in the 2-mg group was longer than in the other groups (P < 0.001); there were no other significant differences among the groups.ConclusionsThe reversal of sugammadex from a deep rocuronium-induced NMB during large pretreatment of MgSO4 was not affected. However, we should consider that the reversal effect of sugammadex varied depending on the dose.http://ekja.org/upload/pdf/kjae-70-203.pdfmagnesium sulfatepharmacodynamicsrabbitsrocuroniumsugammadex |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Woon Seok Kang Kyo Sang Kim Shin Mi Song |
spellingShingle |
Woon Seok Kang Kyo Sang Kim Shin Mi Song Reversal with sugammadex for rocuronium-induced deep neuromuscular block after pretreatment of magnesium sulfate in rabbits Korean Journal of Anesthesiology magnesium sulfate pharmacodynamics rabbits rocuronium sugammadex |
author_facet |
Woon Seok Kang Kyo Sang Kim Shin Mi Song |
author_sort |
Woon Seok Kang |
title |
Reversal with sugammadex for rocuronium-induced deep neuromuscular block after pretreatment of magnesium sulfate in rabbits |
title_short |
Reversal with sugammadex for rocuronium-induced deep neuromuscular block after pretreatment of magnesium sulfate in rabbits |
title_full |
Reversal with sugammadex for rocuronium-induced deep neuromuscular block after pretreatment of magnesium sulfate in rabbits |
title_fullStr |
Reversal with sugammadex for rocuronium-induced deep neuromuscular block after pretreatment of magnesium sulfate in rabbits |
title_full_unstemmed |
Reversal with sugammadex for rocuronium-induced deep neuromuscular block after pretreatment of magnesium sulfate in rabbits |
title_sort |
reversal with sugammadex for rocuronium-induced deep neuromuscular block after pretreatment of magnesium sulfate in rabbits |
publisher |
Korean Society of Anesthesiologists |
series |
Korean Journal of Anesthesiology |
issn |
2005-6419 2005-7563 |
publishDate |
2017-04-01 |
description |
BackgroundMagnesium sulfate (MgSO4) has been used in the treatment of pre-eclampsia, hypertension and arrhythmia. Magnesium enhances the neuromuscular block of rocuronium. This study has been conducted to evaluate the reversal efficacy of sugammadex from deep rocuronium-induced neuromuscular block (NMB) during consistent pretreatment of MgSO4 in rabbits.MethodsTwenty-eight rabbits were randomly assigned to four groups, a control group or study groups (50% MgSO4 150–200 mg/kg and 25 mg/kg/h IV), and received rocuronium 0.6 mg/kg. When post-tetanic count 1–2 appeared, sugammadex 2, 4, and 8 mg/kg was administered in the 2-mg group, control and 4-mg group, and 8-mg group, respectively. The recovery course after reversal of sugammadex administration was evaluated in each group.ResultsThe mean serum concentration of magnesium was maintained at more than 2 mmol/L in the study groups, and the total dose of MgSO4 was more than 590 mg. The reversal effect of sugammadex on rocuronium-induced NMB in pretreated MgSO4 was not different from that in the group without MgSO4. The recovery time to train-of-four ratio 0.9 after sugammadex administration in the 2-mg group was longer than in the other groups (P < 0.001); there were no other significant differences among the groups.ConclusionsThe reversal of sugammadex from a deep rocuronium-induced NMB during large pretreatment of MgSO4 was not affected. However, we should consider that the reversal effect of sugammadex varied depending on the dose. |
topic |
magnesium sulfate pharmacodynamics rabbits rocuronium sugammadex |
url |
http://ekja.org/upload/pdf/kjae-70-203.pdf |
work_keys_str_mv |
AT woonseokkang reversalwithsugammadexforrocuroniuminduceddeepneuromuscularblockafterpretreatmentofmagnesiumsulfateinrabbits AT kyosangkim reversalwithsugammadexforrocuroniuminduceddeepneuromuscularblockafterpretreatmentofmagnesiumsulfateinrabbits AT shinmisong reversalwithsugammadexforrocuroniuminduceddeepneuromuscularblockafterpretreatmentofmagnesiumsulfateinrabbits |
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