Discovery, Function, and Therapeutic Targeting of Siglec-8

Discovery, Function, and Therapeutic Targeting of Siglec-8

Siglecs (sialic acid-binding immunoglobulin-like lectins) are single-pass cell surface receptors that have inhibitory activities on immune cells. Among these, Siglec-8 is a CD33-related family member selectively expressed on human mast cells and eosinophils, and at low levels on basophils. These cel...

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Bibliographic Details
Main Authors: Bradford A. Youngblood, John Leung, Rustom Falahati, Jason Williams, Julia Schanin, Emily C. Brock, Bhupinder Singh, Alan T. Chang, Jeremy A. O’Sullivan, Robert P. Schleimer, Nenad Tomasevic, Christopher R. Bebbington, Bruce S. Bochner
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cells
Subjects:
Siglec-8
mast cells
eosinophils
monoclonal antibodies
glycan ligands
AK002
Online Access:https://www.mdpi.com/2073-4409/10/1/19

Internet

https://www.mdpi.com/2073-4409/10/1/19

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