Interaction analysis of statistically enriched mutations identified in Cameroon recombinant subtype CRF02_AG that can influence the development of Dolutegravir drug resistance mutations

Abstract Background The Integrase (IN) strand transfer inhibitor (INSTI), Dolutegravir (DTG), has been given the green light to form part of first-line combination antiretroviral therapy (cART) by the World Health Organization (WHO). DTG containing regimens have shown a high genetic barrier against...

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Bibliographic Details
Main Authors: Sello Given Mikasi, Darren Isaacs, Rumbidzai Chitongo, George Mondide Ikomey, Graeme Brendon Jacobs, Ruben Cloete
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Infectious Diseases
Subjects:
Online Access:https://doi.org/10.1186/s12879-021-06059-x